Cyclobenzaprine StatPearls NCBI Bookshelf
It is also being investigated in a rapid-release form as a treatment for post-traumatic stress disorder since the medication has similar effects on the brain as tricyclic antidepressants. Signs of overdose include chest pain, hallucinations, vomiting, rapid heartbeat, slurred speech, difficulty breathing, and extreme drowsiness. The risk of overdose is significantly increased when Flexeril is combined with other drugs, particularly alcohol or Benzodiazepines.
Cyclobenzaprine is typically prescribed to relieve pain and muscle spasms. Typically, muscle spasms occur in an injury to stabilize the affected body part and prevent further damage. It is believed that by decreasing muscular spasm, pain is diminished. A common application would be that of a whiplash injury in a car accident.
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Using saturation radioligand binding, we also demonstrate that cyclobenzaprine binds to the H1R in a non-competitive manner. Cyclobenzaprine is related structurally and pharmacologically to the tricyclic antidepressants (TCAs). Like other SMRs, cyclobenzaprine produces its effects within the CNS, primarily at the brainstem level.
Before taking cyclobenzaprine,
Withdrawal symptoms consisting of nausea, headache, and malaise have been reported following abrupt cessation of cyclobenzaprine after prolonged use. Flexeril is prescribed to treat short-term pain and discomfort that stems from muscle injuries, including strains, sprains, and spasms. Typically, a doctor will prescribe Flexeril as part of a treatment plan that also includes rest and physical therapy. In some cases, Flexeril can be used in order to treat pain from certain musculoskeletal disorders like fibromyalgia.
It is available in the form of tablets and extended-release capsules. Studies have compared cyclobenzaprine, methocarbamol, and other skeletal muscle relaxants and found that they are equally effective in treating acute musculoskeletal conditions. Cyclobenzaprine is one of the most studied skeletal muscle relaxants, with solid evidence and systematic reviews supporting its effectiveness. A case of cyclobenzaprine (flexeril) overdose and the resultant rhabdomyolysis is presented. A review of the range of clinical toxicity, management of overdose is described. The similarity of cyclobenzaprine to the tricyclic antidepressant class is emphasized; this report attempts to disseminate related information on this commonly prescribed centrally acting muscle relaxant.
- Cyclobenzaprine comes as a tablet and an extended-release capsule to take by mouth.
- The extended-release capsule is usually taken with or without food once a day.
- Muscle relaxants are frequently used as an adjunct to other medications (mostly NSAIDs) in patients with myofascial pain.
- Typically, a doctor will prescribe Flexeril as part of a treatment plan that also includes rest and physical therapy.
- A common application would be that of a whiplash injury in a car accident.
Flexeril usually takes between 45 minutes to an hour to work after being ingested to show relaxation activity. It peaks at around 3 to 4 hours, and then the effects begin to wear off. In the case of an extended-release formulation, the effects last for up to 24 hours.
– Cyclobenzaprine
Although it is an unscheduled drug with a relatively low potential for abuse, people can develop compulsive patterns of use with cyclobenzaprine, which can lead to serious consequences. Cyclobenzaprine medications are not DEA Scheduled drugs and, therefore, the potential for misuse and dependence with Flexeril is considered to be relatively low. Muscle relaxants are frequently used as an adjunct to other medications (mostly NSAIDs) in patients with myofascial pain. Easily book a session with our online doctors to assist you with a wide range of non-life-threatening illnesses (including mental health conditions) from the comfort of your own home. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital.
Whether cyclobenzaprine is superior to other drugs for the management of acute myofascial strain is unclear and it usually adds more side effects with little therapeutic gain (Turturro et al 2003). For neck pain, however, mixed results are obtained (Peloso et al 2005). There are no extensive studies on the use of cyclobenzaprine in the management of painful orofacial musculoskeletal conditions. The results suggest can i take tramadol with flexeril that cyclobenzaprine is superior to both placebo and clonazepam when added to self-care and education for the management of jaw pain upon awakening. In this study cyclobenzaprine (10mg/d) failed to significantly improve sleep in the short term but this may have been due to the relatively low dose employed. The usual dose is 5–10mg three times daily and treatment for more than 2–3 weeks is not recommended.
A new, controlled-release formulation of the drug is now available and appears to have a more favorable side-effect profile when compared with the immediate-release formulation. Cyclobenzaprine is a centrally acting skeletal muscle relaxant structurally related to tricyclic antidepressants. Cyclobenzaprine is a tricyclic amine salt that works in the central nervous system (CNS) as a depressant that reduces muscle hyperactivity. Cyclobenzaprine (flexeril) after its synthesis in 1961 was found to have limited antidepressant action with no significant advantage over other tricyclic antidepressants[1]. However it was found to act as a centrally acting muscle relaxant and has been widely used ever since.
Professional resources
Join the thousands of people that have called a treatment provider for rehab information. Cyclobenzaprine doesn’t seem to be particularly popular in recreational drug-using communities, despite having an arguably high potential for abuse. Ask your pharmacist any questions you have about refilling your prescription.